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The C34 trimeric molecule was previously designed and synthesized using a novel template with C3-symmetric linkers by us.
Three series of novel 2-methylpiperazine derivatives were designed and synthesized using a fragment-assembly strategy.
A fused benzimidazole imidazole scaffold was designed and synthesized using a facile procedure involving deprotection and cyclization reactions.
A series of novel bi-functional reagents were designed and synthesized using a concise, five-step sequence.
A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach.
Based on a putative 'Y shape' pharmacophore model of CCR5 inhibitors, a series of novel piperidine-4-carboxamide derivatives were designed and synthesized using a group-reverse strategy.
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A series of novel and potent 3-amidinophenylsulfonamide derivatives of factor Xa inhibitors were designed and synthesized using an amidoxime prodrug strategy.
In this study, two series of new pyrimidine derivatives were designed and synthesized using an efficient route, and were evaluated in terms of GLP-1 receptor agonist activity.
A new soluble n-type material based on the 2,9-bis triisopropylsilylethynyl triphenodioxazine (TIPS-triphenodioxazine) has been designed as a quinonoid equivalent of TIPS-pentacene and synthesized using an innovative synthetic pathway.
Based on the bioisosteric principle, novel series of 1,2,3-selenadiazole thioacetanilide derivatives were designed, and synthesized using an original synthetic route, structurally confirmed by spectral analysis, and evaluated for their anti-HIV activity in MT-4 cells.
New multipotent antioxidants (MPAOs), namely 1,3,4-thiadiazoles and 1,2,4-triazoles bearing the well-known free radical scavenger butylated hydroxytoluene (BHT), were designed and synthesized using an acid- base-) cacid- base-tramolecatalyzedydratintramolecularn reaction of the correspondehydrativethiosemicyclization
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