The association of natriuretic peptides and survival was explored in a series of ROC curves (Fig. 4).
In addition, the relation between HJURP expression and survival was explored in microarray data sets by dividing the cases from each cohort into a group with high (top one-third), moderate (middle one-third), and low (bottom one-third) level of expression.
The functional relationships between CIT and initial organ function and patient and graft survival were explored through regression analysis of the subgroup data.
The relationships between clinicopathological features, treatment and both cancer-specific and overall survival were explored by multivariate proportional hazards analyses and results shown in Table 2. Increasing age (p = 0.018) and involved numbers of lymph nodes (p < 0.001) were associated with poorer cancer specific survival in univariate analysis.
Drug retention was examined using survival analysis, and differences in drug survival were explored with a Cox proportional hazard model.
The correlation of RAD21 gene expression to 10-year relapse-free survival was explored in a validation cohort of 215 breast cancer patients, with tumors previously characterized on the Illumina Human RefSeq-8 microarray, by Buffa et al. [ 23].
Associations with cancer-specific survival (CSS) were explored by Cox proportional hazards regression, unadjusted and adjusted for age, TNM stage, differentiation grade, vascular invasion and microsatellite instability (MSI) status.
Associations between patient characteristics (age, gender) or disease characteristics (primary tumor type, extracranial disease status, number of metastases, location of metastases, time from primary tumor diagnosis to development of brain metastases, total tumor volume, total treatment volume) and the outcomes of overall survival and distant failure were explored.
