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The phrase "and substantive impact on" is correct and usable in written English.
It can be used when discussing the significant effects or consequences of an action, policy, or event on a particular subject or area.
Example: "The new policy is expected to have a positive and substantive impact on employee productivity."
Alternatives: "and significant effect on" or "and meaningful influence on".
Exact(2)
By contrast, theories about the aim or goal of belief typically have an immediate and substantive impact on conceptions of its ethics, and can be used, in particular, to answer questions about the relative importance of various norms, whether there are "all things considered" obligations in a given situation, and so on(see Velleman 2000, Wedgwood 2002, and Shah 2003 for general discussion).
Perhaps this is why college hoops have made such a remarkable and substantive impact on education at the University of Kentucky.
Similar(58)
Housing assistance, he said, "is an investment that has an immediate return and a substantive impact on people that are living below the poverty line".
"It has redefined our understanding of the public sphere to be more inclusive and more accessible and to have substantive impact on real-world events".
We conclude that a vaccine of moderate efficacy and duration could have a substantive impact on gonococcal prevalence, and disease sequelae, if coverage is high and protection lasts over the highest risk period (i.e., most sexual partner change) among young people.
Results demonstrate the difficulty in successfully achieving diets with desired PF and k values, and in achieving diets with ranges in PF, but that changes in diet PF and k had no substantive impact on intake, digestion, N balance, milk production or MN supply to the duodenum.
They could grow into a modern version of the Civil Rights Movement and have a lasting, substantive impact on America.
Since this was a small study (effective sample size of 36), we judge that full integration of outcome data from this study into meta-analyses (1) and (2) will have no substantive impact on current estimates of summary effect sizes.
But every so often, someone says something that has real, unexpected, substantive impact on their candidacy and the conversation.
The experience in Kenya highlights how such a network can empower the youth to have a substantive impact on the prevention and mitigation of NCDs in their local context.
Several authors have suggested the founding period as a critical time in the development of a firm, arguing that the resource and decision choices made at this point have a substantive impact on the firm's future.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com