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The phrase "and substantive differences in" is correct and usable in written English.
It can be used when discussing notable or significant distinctions between two or more subjects or concepts.
Example: "The study revealed both procedural and substantive differences in the approaches taken by the two organizations."
Alternatives: "and significant variations in" or "and meaningful distinctions in".
Exact(2)
We determined whether or not we met this objective by testing the hypothesis that there are statistically significant and substantive differences in key characteristics across DPBRN regions, based on responses to the DPBRN Enrollment Questionnaire from dentists who participated in DPBRN's first network-wide study.
We can conclude that our objective was indeed met because we were able to document statistically significant and substantive differences in key characteristics within and between DPBRN regions, based on responses to the DPBRN Enrollment Questionnaire from dentists who participated in DPBRN's first network-wide study.
Similar(58)
Nevertheless, the clinical data presented herein admittedly are from different trials (ATAC and BIG 1 98) that were conducted at different times and with different overall goals, and with substantive differences in study design, population, and follow-up reporting of results.
A recent report from the U.S. National Health Interview Survey NHISS) disaggregated API subgroups and found substantive differences in diabetes prevalence (3).
Although ever users of HT were also more likely than never users to have a history of preventive screening, they were less likely to be obese and showed no substantive differences in previous family history of colorectal cancer compared with never users.
In Savino's trial [ 60], the percentage reduction in median daily crying time at day 28 compared to baseline was 70% for the probiotic and 26% for simethicone, suggesting substantive differences in this outcome are likely.
This variability has prevented us from reaching conclusions regarding the optimal approach to airway management in early resuscitation due to the inability to appropriately account for covariates affecting patient outcomes, substantive differences in EMS system and provider characteristics, and intubation protocols.
Reassuringly, we found that there were few substantive differences in our results when considering different methods and datasets; moreover, trends tended to be clearly preserved with the main differences appearing to stem from diminished statistical power when using the smaller data sets.
Our comparison of the percentiles of the distributions of the plausible values based on the five rotation models and the original plausible values revealed no substantive differences in any of the domains.
When stratifying by age we did not find any substantive differences in our results and thus we will only be presenting data analysing our preschooler population as a whole.
A survey for mast cell profiles in tissues of white (n = 2) and pigmented cats (n = 2) revealed no substantive differences in mast cell distribution (Table S10).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com