The phrase "and substantive changes to" is correct and usable in written English.
It can be used when discussing modifications or alterations that are significant in nature, often in legal, academic, or formal contexts.
Example: "The committee proposed a new policy that includes financial adjustments and substantive changes to the existing regulations."
Alternatives: "and significant modifications to" or "and meaningful alterations to".
On Sunday, in a Sky interview, Cameron said that there would be "proper and substantive changes" to the bill setting up the new GP-led consortiums at the end of the two-month pause in its passage through parliament.
We will make changes, we'll make significant and substantive changes to the legislation which at the moment is – if you like – it's suspended in the House of Commons, in order to make sure that those who perhaps develop some very serious and legitimate doubts about some of the details of the plans feel that it's now on the right track again and then we can move forward together".
Yet the most evident and substantive change to the game has been to its economics, and the degree to which at the highest level this has separated those who play football from those who watch it.
Protesters in the square, the epicenter of the antigovernment protests that toppled the government just weeks ago, celebrated the new prime minister, Essam A. Sharaf, while also continuing to press for faster and more substantive changes to promote democracy.
The Health Secretary, Andrew Lansley, says there will be a chance to pause and make substantive changes to the bill as it goes before parliament.
It is the second logician Ibn Khaldûn mentions who, it would seem, made more, and more substantive, changes to Avicennan logic: Afdaladdîn al-Khûnajî (d. 1249).
Three days later, Foster Farms "submitted and implemented immediate substantive changes to their slaughter and processing to allow for continued operations".
The reality is that as you validate the commercial hypotheses (i.e. clinical utility, customer, quality of data, reimbursement, what parts of the product are valuable, roles of CRO's, and partners, etc.,) you make substantive changes to one or more parts of your initial business model, and this new data affects your biological and clinical hypotheses.
Mr. Boehner wants a far larger pledge and a firm commitment that Mr. Obama will put his political weight behind substantive changes to Medicare and the tax code.
"The absence of substantive changes to targets and policy illustrates that there are often constraints to major policy shifts".
