Sentence examples for and substantial variability of from inspiring English sources

Previous studies have concluded that causes of death are associated with issues of inaccuracy and substantial variability of coding according to cancer type, age at death and time period [ 8, 11– 16].

Establishing reliable estimates of national and regional disease burden has been challenging because of the lack of standard assays for hepatitis E testing and substantial variability in the quality of commercial assays (10, 11 ).

The cytokines IL-2 and IL-4 were below detection levels for most animals and likewise, substantial variability of IFN-g precluded detection of any reliable between group differences.

Even though the manifestation of the basic defect at the cellular and epithelial levels is less vulnerable to environmental influences than any clinical outcome parameter such as lung function, growth and stature, substantial variability of the basic defect phenotype among sib pairs with shared CFTR mutation genotype is observed.

Nevertheless, not all lead studies have found this association, and substantial variability exists in the magnitudes of the reported effects [ 8].

Estrogens and other hormones with growth enhancing properties are abundant during pregnancy, and adult life exposures do not fully explain the substantial variability of breast cancer occurrence between and within populations.

This is largely due a substantial variability of plasma MMP8 and MMP9 in patients without AAD, which leads to negligible specificity and positive predictive value of these markers.

The substantial variability of DCD expression in primary tumours and cell lines and lack of reliable methods of DCD induction in vitro may require development of new model systems (perhaps based on the MIA-Pa-Ca-2 cell line) and novel detection methods for the DCD protein itself.

Gruau et al. [7] found substantial variability of δ18Op within P sources and considerable overlap of δ18Op among different P sources and therefore questioned the value of this method as a research tool.

Although the custom array card included internal controls (U6 and RNU66 for mature miRNAs; beta-actin and GAPDH for the precursors) in the panel, we could not rely on these controls to normalize the data because of the substantial variability of these genes expressed in tissues and cells (Tables S3, S4 and S5).

This finding is consistent with the substantial variability of symptoms in this region, in which both neurotoxic and classical envenomations are reported (Figure 14).