The phrase "and substantial clinical data" is correct and usable in written English.
It can be used when discussing research, studies, or findings that are supported by significant evidence from clinical trials or observations.
Example: "The new treatment has shown promising results, supported by substantial clinical data from recent trials."
Alternatives: "and significant clinical evidence" or "along with considerable clinical data."
It is therefore reasonable to expect that the sensitivity and specificity of the alpha-defensin test in this study should approximate these previous publications that included substantial clinical data.
Despite substantial clinical data demonstrating the superiority of platinum-based regimens vs non-platinum regimens, the non-inferiority of carboplatin over cisplatin, and the benefit of paclitaxel combined with platinum-based regimens, the molecular basis to OVCA sensitivity to these drugs remains to be fully characterised.
Although meeting the regulatory criteria to approve biosimilar medication for a given indication on the basis of comparative studies with the reference product may be sufficient to support switching, substitution of insulins at the pharmacy level will require more substantial clinical data.
On the other hand there is vast experience with and substantial clinical trial data for so-called selective digestive tract decolonization (SDD) regimens in intensive care patients and in neutropenic cancer patients in whom preventive treatment with nonabsorbable drugs like colistin plus tobramycin can decrease the risk of infection due to gram-negative enteric bacteria [ 6].
WCL, NWT, WNC, CRH, TLH, HCL, YJL, BCC, YJ S, and CTK had substantial contributions to the conception and design, and clinical data analysis.
Substantial preclinical and clinical data suggest that pathogenic B cells contribute to SLE pathogenesis by complex mechanisms including autoantibody production, antigen presentation, and cytokine generation (5).
In the future, substantial molecular and clinical data must be compiled to provide the necessary proof of concept of the systems approach and the hypotheses developed within the described systems concept.
There is substantial experimental and clinical data supporting the safety of creatine supplementation when it is used in the recommended amounts, but there is concern that excess dietary protein and creatine that is not accompanied by increased fluid intake may lead to a relative hypovolemia [ 6– 9].
Even if the intervention proves not to be beneficial substantial additional clinical data about the natural history of AVFs, use of CVCs and long term outcomes of AVF surgery will inform clinical practice.
Considering that long-term therapy is required in the adjuvant setting or as a part of cancer prevention strategies, candidate prevention or treatment medications will need substantial clinical safety data to be considered for study.
