Residues such as glutamate, serine and threonine have been found to be crucial in the tight helical packing of membrane bound proteins, which in turn contributes to the stability, folding and subsequently, the function of the protein [46].
Therefore, GSNOR has an important role in regulating intracellular SNOs and, subsequently, the function of these compounds [ 11], while dysregulation of this enzyme can lead to deleterious effects as observed in respiratory and other diseases [ 12, 13].
For example, it has been demonstrated that the success of a CI is dependent on the proper transduction of electrical signals and subsequently on the function of the AN [ 4, 5].
Third, the identification of COGs of the SET domain genes ranging from yeast to human provides a fundamental framework, by which one can integrate the large amount of information about these SET domain genes in various species obtained from the structural and functional studies, and subsequently predict the function of any gene member that has not been well studied.
In Toxoplasma gondii, Mullapudi et al. (2009) identified putative cis-regulatory elements present upstream of functionally related groups of genes and subsequently characterized the function of some of these conserved elements using reporter assays in the parasite [ 18].
Our approach unites the pathway-guided and module-guided methods in that we group the pre-selected set of known and putative genes from pathways into modules, and subsequently assign the function to those putative candidates that are within the module.
While the mechanism by which THz radiation couples to, and subsequently affects, the function of biomolecules (e.g., DNA and proteins), remains unclear, there is ample evidence that exposure to THz radiation can affect the intramolecular vibrations and hence dynamically induce new conformational states [ 21, 22, 25, 26].
Akt has been reported to phosphorylate and subsequently regulate the function of several downstream effectors: potential downstream targets of Akt include the pro-apoptotic protein Bad, which is inactivated by Akt-mediated phosphorylation [ 29, 30] and the Forkhead (FHKR) family transcription factors [ 31, 32].
Notably, studies found that nebulized colistin reduced the number of relapses of lung infections and subsequently the decline in lung function among patients with cystic fibrosis [ 24- 27].
This results in a non-equally sampled data set, which (after calculating the creep compliance) can be well handled by both the MSD_to_J function and subsequently the numerical conversion method J_to_G, resulting in an improved complex shear modulus.
The aim of this paper is to demonstrate on the basis of the author's own mathematical models of across-wind load on a slender structure of circular cross-section at vortex excitation, that the correlation function and, subsequently, the power spectral density of this load can be described by universal formulas of two functional parameters which should be determined experimentally.
