Sentence examples for and subsequently suppressed from inspiring English sources

Our data demonstrate that administration of gremlin siRNA plasmid to diabetic mice alleviated renal hypertrophy, cell proliferation and apoptosis, and subsequently suppressed collagen type IV accumulation and mesangial expansion, indicating beneficial effects of Gremlin inhibition on diabetic nephropathy.

Different effects of purified HIV-1 proteins on CSR have previously been reported [20], [21] where nef was shown to be taken up by B-cells and subsequently suppressed CSR by inducing IκBα and SOCS proteins, thereby blocking CD40 ligand and cytokine signalling via NF-κB and STAT proteins.

Wu et al. found overexpression of miR-142-3p miR-142-3p miR-142-3pn levels andecreasedently suppRAC1ed migration and invasion of HCC cell lines (SMMC7721and QGY7703) [ 9].

In particular, HOXB13 inhibited the expression of TCF4 and subsequently suppressed the expression of TCF-responsive genes, including c-myc and cyclin D1.

Accumulating evidence showed that Res decreased miR-520 h and subsequently suppressed tumor cell invasion and migration in lung cancer cells [ 12].

This study reveals the involvement of PI3K-Akt signaling through which ellagic acid induces apoptosis and subsequently suppresses colon cancer during DMH-induced rat colon carcinogenesis.

At last, pretreatment with LSD1 inhibitor TCP in HBV-Tg mice could downregulate TLR4 expression and subsequently suppress degradation of IκBα and phosphorylation of IKKα/β, IκBα, and JNK, thereby possibly inhibiting the expression of proinflammatory mediators.

Thus, obstacle of any one mechanism of the growth of tumor cells and endothelial cells, would be able to inhibit tumor cell growth, and subsequently suppress tumor proliferation.

Open image in new window Figure 1 mTORcomponentsnts and S6K interact with different domains of Sin1 Open image in new window Figure 2 Phosphorylation of Sin1 at both T86 and T398 sites dissociates Sin1 from functional mTORC2 complex and subsequently suppresses Akt activation.

In an acute model of hyperoxia-induced retinal ischaemia, administration of exogenous EPO prior to the hypoxic insult can protect neurons, prevent vessel dropout and subsequently suppress the stimulus for hypoxia-induced neovascularisation [18].

Etomoxir inhibits mitochondrial carnitine palmitoyltransferase-1 (CPT-1) and subsequently suppresses long-chain FFA oxidation [ 70].