Quantifying mechanically-induced changes in the tricuspid valve extracellular matrix (ECM) structural components, e.g. collagen fiber spread and distribution, is important as it determines the overall macro-scale tissue responses and subsequently its function/malfunction in physiological/pathophysiological states.
So, whereas an adaptation is the product of natural selection favoring variants on the basis of, and gradually improving, the current function, an exaptation is a feature that arose for some other reason and subsequently acquired its current function.
These findings suggested that the AKT pathway might regulate p57 subcellular localization and subsequently affect its biological function.
The progressive accumulation of collagen develops a range of ventricular dysfunctional processes that generally affect diastolic and subsequently systolic function [4].
Residues such as glutamate, serine and threonine have been found to be crucial in the tight helical packing of membrane bound proteins, which in turn contributes to the stability, folding and subsequently, the function of the protein [46].
Furthermore, changes in the fatty acid composition of skeletal and cardiac muscles, caused by fish oil consumption, affected physical properties of the cell membranes and subsequently muscle function in a rat model [29], [30].
This may then limit muscle regeneration post-operatively, and subsequently physical function.
Proteomic analysis techniques provide information regarding functions developed by sperm proteins, also identifying post-translational modifications able to affect protein and subsequently sperm function.
In addition to the structural contributions, turgor pressure also affects physical conditions within the cell and subsequently cellular function and biochemistry.
Indiscriminate or inappropriate use of immobilization through splinting may result in joint stiffness, prolonged pain, oedema and subsequently reduced function[ 15].
Genome regions with a large number of CpG-SNPs in LD are therefore likely to affect the chromatin structure and subsequently gene function.
