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Here we report on the evaluation of clot-targeting efficacy, lipase-triggered drug release and resultant thrombolytic capability of the PMINs in vitro, and subsequently demonstrate that intravenous delivery of thrombolytic-loaded PMINs can render targeted fibrinolysis without affecting systemic hemostasis, in vivo, in a carotid artery thrombosis model in mice.
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It was postulated (and subsequently demonstrated) that this actinoid series started at thorium and that its chemistry would be similar to that of the lanthanoids.
This article applies DL to identify the presence and location of tubules in breast pathology images and subsequently demonstrates that the number of detected tubules correlates with the risk assessments of breast cancer via a genomic test.
The researchers proceeded to develop techniques to overcome obstruction, such as lifting of the chin, and subsequently demonstrated that mouth-to-mouth respiration was superior to other methods in the quantity of air that could be delivered in each respiratory cycle (tidal volume).
Cavelti first identified anticardiac autoantibodies in ARF in 1945, and subsequently demonstrated that anticardiac and antiskeletal muscle antibodies were produced in rats, but only in the presence of killed streptococci.
Recently, Dalbeth et al. showed enhanced osteoclastogenesis in patients with chronic tophaceous gout [ 9], and subsequently, demonstrated that gouty tophi represent an organized chronic inflammatory tissue response involving both innate and adaptive immune cells to MSU crystals [ 10].
In addition, in previous studies, we confirmed the strong activation of recA expression by ciprofloxacin in S. aureus and subsequently demonstrated that aminocoumarins (novobiocin) lead to the repression of recA expression (Schroder et al. 2013).
The current study initially verified that the effectiveness of Gln as a GLP-1 secretagogue is observed in primary colonic cultures as well as GLUTag cells, and subsequently demonstrated that this is attributable to the activation of both a triggering pathway that elevates intracellular calcium (Cai2+), and an amplifying pathway mediated by elevated cAMP.
We subsequently demonstrate that in the context of this altered binding signature that one of the affected client proteins, RAF1, plays an important role in mediating KBU2046 efficacy.
We subsequently demonstrate that such an arrangement can provide a principled method for the top-down control of attention during action perception, resulting in significant performance gains.
We subsequently demonstrate that such heterozygous diploid strains are more robust to the effects of SCRaMbLE than haploid semisynthetic strains, rapidly improve rationally selected phenotypes in SCRaMbLEd heterozygous diploids, and establish that multiple sets of independent genomic rearrangements are able to lead to similar phenotype enhancements.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com