Sentence examples for and subsequently activation of from inspiring English sources

While the development of necrosis following NO application appears to be independent of cGMP, the development of apoptosis involves cGMP and subsequently activation of mitogen-activated protein kinases and transcription factors [ 46, 49, 50].

Importantly, our findings provide novel evidence suggesting that PKG stimulates cardiac KATP channels primarily through generation of ROS, in particular hydrogen peroxide (H2O2), and subsequently activation of calmodulin and CaMKII, whereas direct PKG phosphorylation of the channel is not involved in channel stimulation.

They are competitive antagonists of the ATP-binding site, inhibiting phosphorylation and subsequently activation of the EGFR receptor.

α2 Receptor mediated cytokine production is regulated via activation of protein kinase C, phosphorylation of IκB and subsequently activation of NF-κB [ 26].

In vitro, HBV replication could be inhibited by stimulating IL-1 receptor and TLR2 receptors and subsequently activation of a signaling cascade in hepatoma cell lines [ 6].

This is a first implementation, and subsequently activation of the adjacent vessel may be a requirement for joining of the tip cell.

Subsequently, activation of Bmp4, Brachyury and Flk1 were all delayed by one to two days.

Subsequently, activation of lipocortin 1 may inhibit the activity of phospholipase A2, regulator of prostaglandins, leucotrienes and platelet activating factor.

Since Tat is the only viral protein known to be released by infected microglial cells [ 55] it may have accounted for the increased protein concentration as we have shown that active gliosis is occurring and this process occurs subsequently after activation of the macro- and microglia, however this is only our speculation.

It has been suggested that CagL binding to β1-integrin leads to the activation of β1-integrin and, subsequently, to activation of several host kinases, including FAK, Src, EGFR and HER3 (heregulin receptor 3)/ErbB3 in an RGD-dependent manner [ 50, 120].

The induction of hid eventually leads to activation of the caspase Dronc and subsequently to activation of the effector caspase Drice.