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The present results further support and extend the knowledge about the mechanism of action for 2OHOA, based on the regulation of the membrane lipid composition and structure and subsequent modulation of membrane protein-associated signaling.
Interestingly, a higher prevalence of helminthic coinfection has been observed among infected individuals, and subsequent modulation of the immune response typically associated with helminths may influence clinical outcomes among HTLV-1 coinfected individuals.
This effect may be mediated through CREB pathway and subsequent modulation of glutamate receptor subunits expression.
This effect appears to be mediated through pAkt-pCREB pathway and subsequent modulation of glutamate receptor subunits expression.
We suggest that in one pathway, P influences anxiety following its metabolism to neuroactive steroids and subsequent modulation of the GABAA receptor, indeed there is an overwhelming amount of evidence for this mechanism [44].
Ligand binding induces a conformational change in the receptor that allows for differential recruitment of cofactors and subsequent modulation of NHR activity [ 3– 6].
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Rituximab has been shown to exert its antitumor activity in vitro by attenuating constitutively active AKT and subsequent modulation expression of the antiapoptotic proteins of the BCL-2 family.
However, the host response to pathogens is both complex and extensive, consisting of both the cell sensing the presence of the pathogen and activating defense pathways and the subsequent modulation of these cellular pathways by the pathogen.
The transmembrane domain (TMD) of KCNE1 plays a key role in mediating the physical association with KCNQ1 and in subsequent modulation of channel gating kinetics and conductance.
Its binding to fibrin and the subsequent modulation of protease activity are regulated primarily by the F and K2 domains, respectively.
Various studies indicate the involvement of certain transcription factors in the regulation of miRNA expression and the subsequent modulation of pathological conditions in cancer.
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