Whether the specification of eye-field cells and subsequent induction of neural retina cells occur in a single or distinct inductive event, and how this is regulated is not known.
Toll-like receptors (TLRs) are important pattern recognition receptor family for the detection of foreign nanomaterials and subsequent induction of innate immune process [25].
In general, most cells can tolerate a certain amount of ROS, whereas higher levels of ROS persist over a longer time and may result in cell damage and subsequent induction of toxic effects (Wang et al. 2007).
This results in DevR binding to DNA via its C-terminal domain (DevRC) and subsequent induction of the DevR regulon.
In these cells prdm1 functions within the context of a Notch-bHLH pathway since sensory neurogenesis also requires downregulation of Notch signalling and subsequent induction of ngn1 [28].
Thus, induction of aiCD4+ T cells is a critical step, and subsequent induction of effector CTL is a critical next step in the development of autoimmunity [21], [22].
Shifting the cellular redox balance through pharmacologic manipulation in favor of increasing intracellular ROS may lead to oxidative stress and subsequent induction of apoptosis within cancer cells.
As previously discussed [43], Vpr docking at the NE could constitute a prerequisite for binding to DCAF1 and subsequent induction of cell cycle arrest.
TLR activation initiates intracellular signaling resulting in activation of transcription factors such as AP-1 and NFκB and subsequent induction of inflammatory cytokines [25], [26].
Sixth, Wnt5a derived from endothelia signals through Fzd5 to induce the translocation of NFAT and subsequent induction of IL-2 in T cells [10].
This effect was attributed to DNA hypomethylation and subsequent induction of strand breaks within the APC gene leading to decreased expression of APC mRNA.
