Sentence examples for and subsequent hyperactivation of from inspiring English sources

In our study, Tanshinone IIA treatment was able to effectively mitigate GSK3β overactivity and subsequent hyperactivation of MAPK pathways in the injured kidney.

Intracellular alkalinization triggers CatSper activation and subsequent hyperactivation of motility in mice.

KRAS mutations and subsequent hyperactivation of RAS signalling pathway is a molecular hallmark of pancreatic cancer.

Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR).

Obesity has been linked with increased endoplasmic reticulum stress, which leads to suppression of insulin receptor signaling via hyperactivation of Jnk and subsequent serine phosphorylation of IRS-1 [ 23].

In breast cancer, increased expression of EGFR or its EGF-like ligands and hyperactivation of subsequent mitogen-activated protein kinase (MAPK) and protein kinase B (AKT) signalling have been linked to anti-hormone resistant growth, metastatic progression and poor prognosis.

Therefore, neuronal atrophy and reduction of cell size are likely associated with a hyperactivation of AMPK and subsequent suppression of protein synsthesis.

Similar to parthanatos cell death, loss of cell membrane integrity and propidium iodide staining, as well as hyperactivation of PARP and subsequent accumulation of PAR polymers were observed upon hCNT1 overexpression.

While progressive motility is essential for spermatozoa to travel through the cervix to the oviduct, the vigorous and asymmetrical swimming pattern of hyperactivation aids the release of spermatozoa from the oviductal epithelium (Demott and Suarez, 1992) and subsequent penetration of the oocyte cell membrane (Stauss et al., 1995).

NF2-deficient Schwannoma cells display aberrant membrane ruffling and concomitant hyperactivation of Rac and Pak1 [10] [11], [11].

We speculate that this could lead to hyperactivation of Rap1 and consequent hyperactivation of β1-integrin.