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A proposed mechanism for such propagation is a prion-like, seed-dependent conformational change and subsequent aggregation of the molecule, with a breakdown of the aggregate that generates the next seeds.
Another mechanism that can contribute in this effect is insufficient surfactant to cover the surface of larger droplets and also coalescence of droplets during the removal of organic phase and subsequent aggregation of NPs.
One of the mechanisms that cause chill injuries in cells is the denaturation and subsequent aggregation of proteins [1], [2].
Given the strong metal-binding properties of MT, we predict that these proteins may be involved in regulating the metal-binding and subsequent aggregation of Aβ.
However, all these apyrases are cation-dependent enzymes that release inorganic phosphate (Pi) from ATP and ADP but not from AMP, thereby inhibiting the purinergic activation and subsequent aggregation of thrombocytes [9], [11].
Because alpha-synuclein is at least in part degraded by the lysosome, decreased activity of GBA could lead to incomplete degradation and subsequent aggregation of alpha-synuclein.
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Random collisions and subsequent aggregation (sticking together) of snow crystals are another reason for flakes to be different.
This probably means that the E. coli BAM complex didn't recognize the C-terminal β-strands of the H. pylori OMPs, and the subsequent aggregation of the OMPs in the periplasm and the blockage of the BAM complex lead to the lethality.
This particular process is related to the molecular weight, the chain entanglement, the molecular transition at elevated temperatures from expanded coils to collapsed globules of a portion of the polymers, and the subsequent aggregation of the collapsed globules to make weak physical junctions.
One interpretation of these results is that aggregation of the less soluble Aβ42 would precede and recruit subsequent aggregation of Aβ40, as has been previously suggested [12], [35].
The exothermic and endothermic peaks observed in Fig. 5a and b are attributed to the coil-helix transitions of the gellan gum molecules and the subsequent aggregation of these helices.
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