Further mechanistic studies indicated that compound 8 significantly suppressed phosphorylation of mitogen-activated protein kinases (MAPKs) and subsequent activation of activator of transcription 1 (AP-1).
In contrast, our studies demonstrate that GTCpFE inhibits IKKα/β activity and subsequent activation of the p65 transcription factor.
These pro-longevity effects result from reduced AMPK catalytic activity and subsequent activation of downstream target Sch9 [ 2].
AMOT may also directly activate Hippo pathway via physical binding to and subsequent activation of Lats1/2 kinase.
Mitogen-activated protein kinase (MAPK) can directly enhance osteogenesis through the phosphorylation and subsequent activation of Runx2 [ 97].
We explain this behavior in terms of dislocation substructure refinement and subsequent activation of deformation twinning.
POMC neurons and subsequent activation of melanocortin 4 receptors were critical for nicotinic-induced decreases in food intake in mice.
Proprotein convertases are serine proteases responsible for the cleavage and subsequent activation of protein substrates, many of them relevant for the development of an ample variety of diseases.
In mice, it is thought that surfactant protein-A induces migration and subsequent activation of amniotic fluid macrophages of fetal origin, which then invades the myometrium.
AD-related cognitive impairment, synaptic loss and neurodegeneration result from interactions of Aβ oligomers with the synaptic membrane and subsequent activation of pro-apoptotic signalling pathways.
We examined how small alterations in the particulate nature of MPs affect both their uptake into and subsequent activation of macrophages.
