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In patients with a history of allergy to penicillin, depending on the nature and severity of the hypersensitivity reactions, the severity of disease and spectrum of coverage needed, suitable alternative antibiotics for empirical coverage include cephalosporins, carbapenems, vancomycin and linezolid.
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The high cost of drug development and the narrow spectrum of coverage typically provided by direct-acting antivirals limit the scalability of this antiviral approach.
This observation has been validated across different platforms and across a spectrum of coverage (Supplementary Fig. S1).
Acknowledgement of this observation has led to the practice of de-escalation where one often starts with an initially broad anti-infective (or a combination of agents) and later narrows the spectrum of coverage when culture results become available [ 15].
Adherence to such guidelines regarding use of antibiotics may positively influence prognosis [ 39], but efforts to improve detection of pathogens should continue because enhanced specificity allows one to focus treatment on the responsible micro-organism and so limit the spectrum of coverage.
Microbiological assessment showed that infection or colonisation by P aeruginosa was not significantly different, both in trials assessing antibiotics with and without an anti-pseudomonal spectrum of coverage (1.06, 0.66 to 1.71, four trials; and 0.89, 0.62 to 1.28, seven trials, respectively).
Companies such as Neutrogena and L'Oréal are increasing the spectrum of coverage.
Unless there are other contraindications (such as severe allergies to beta lactam antibiotics), penicillins (including penicillin V and amoxicillin) or cephalosporins (if a broader spectrum of coverage is clinically indicated) should remain the first-line antibiotics if S. pyogenes infection is suspected clinically.
The proportion of SNP matching dbSNP across a spectrum of coverage levels was calculated and found to increase appreciably from 4 to 14 reads and then plateau afterwards through 30 reads per variant (Additional file 3: Figure S3).
Never do your risk management with an insurance agent unless you are certain you understand the coverage and spectrum of opportunities to manage the risk.
We compared a local ecology based algorithm (LEBA) to a surveillance culture based algorithm (SCBA) in terms of appropriate coverage and spectrum of antimicrobial activity.
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