In our findings, patients with complex regional pain syndrome have substantial spatial alterations in the functional connectivity between brain regions implicated in the resting-state default mode network, S1/M1, and IPS/MIP; these alterations show a trend of correlation with neuropathic pain intensity.
Possibly, tumors' heterogeneity with further additional "spatial" alterations in different metastatic sites could account for this result.
Alzheimer's disease (AD) is characterized by a progressive loss of learning and memory processes and alterations in spatial abilities, confusion, and disorientation.
Following nerve injury, there are spatial and temporal alterations in the expression of MMPs.
More importantly, in some of the material we observed, regions that conventionally disassociate both early and late in the decomposition process are represented as anatomically aligned and articulated groups, suggesting limited post-mortem spatial alteration and disaggregation within the chamber in both the proximate putrefactive (early) and distal decompositional (late) periods.
Impaired navigation in the water maze and spatial alternation in the T-maze suggest an alteration in hippocampus-dependent encoding and/or consolidation of spatial information, in line with the synaptic and neurophysiological alterations observed in Dp71-null mice in this structure.
This prediction points at a precise way in which cellular morphological traits may affect cellular patterning and could be tested by crossing a GL2 GUS or GFP marker line plants with altered cell shapes (e.g. [ 45, 46]) and search for alterations in the spatial pattern of this genetic marker of epidermal cell type.
The origin of the spectral changes in the collagen component of pathological tissue biopsies was traced to increased levels of collagen cross links and alterations in their spatial distribution.
Furthermore, the use of a single or only a few EEG derivations to perform spectral analysis provides limited spatial resolution, and thus, topographic alterations in SWA would not be evident using these approaches.
