Ion channels activated at the terminal shape the presynaptic spike and so regulate the magnitude and duration of calcium entry.
Release probability at a given synapse is dynamic; the ion channels activated at the terminal shape the presynaptic spike and so regulate the magnitude and duration of calcium entry [2], [3], [4].
However, as IgFLN domains can form domain-pairs and so regulate neighbouring domains [36] the Δ19 21 mutation could also exert its effects by modulating ligand binding to adjacent IgFLN domains.
14, 15 The relative concentrations of these molecules enable bacteria to sense β-lactams and so regulate AmpC expression. 2 One strategy to combat inducible AmpC would be to inhibit NagZ using small-molecule inhibitors.
The interaction of CtIP and MRN has been found to regulate the resection of DNA ends [ 35], a process also mediated by BRCA1 [ 36, 37], thereby regulating the function of the ATR-ATRIP complex at regions of ssDNA, and so regulating the progression of the cell through the G2/M checkpoint.
It may be that desmosomes are able to sequester plakoglobin and so regulate its signalling activity in the same way that adherens junctions are apparently able to modulate β-catenin signalling (Gottardi et al, 2001; Kuphal and Behrens, 2006), but this is by no means is certain.
In this paper, we identify a muscle-specific long noncoding RNA (linc-MD1) that displays decoy activity for two specific miRNAs and, in doing so, regulates their targets in a molecular circuitry affecting the differentiation program.
The Ero1α substrate, PDI, is able to reduce the regulatory disulfides within Ero1α in order to activate the enzyme and in doing so regulates the formation of its own active site disulfide [ 16].
It interacts with apoB100 in the Golgi apparatus and accelerates the hepatic synthesis and export of apoB100-containing lipoproteins, and so it regulates the circulating level of LDL-C.
In dry areas, where profligate water-use by one farmer can make many wells run dry, farmers have been persuaded to share information on rainfall, groundwater levels and cropping, and so collectively regulate themselves.
