Ion channels activated at the terminal shape the presynaptic spike and so regulate the magnitude and duration of calcium entry.
Release probability at a given synapse is dynamic; the ion channels activated at the terminal shape the presynaptic spike and so regulate the magnitude and duration of calcium entry [2], [3], [4].
However, as IgFLN domains can form domain-pairs and so regulate neighbouring domains [36] the Δ19 21 mutation could also exert its effects by modulating ligand binding to adjacent IgFLN domains.
While p15INK4b and p16INK4a regulate the Rb-pathway, ARF inactivates MDM2 protein and so regulates p53 [ 51, 52].
14, 15 The relative concentrations of these molecules enable bacteria to sense β-lactams and so regulate AmpC expression. 2 One strategy to combat inducible AmpC would be to inhibit NagZ using small-molecule inhibitors.
The interaction of CtIP and MRN has been found to regulate the resection of DNA ends [ 35], a process also mediated by BRCA1 [ 36, 37], thereby regulating the function of the ATR-ATRIP complex at regions of ssDNA, and so regulating the progression of the cell through the G2/M checkpoint.
It may be that desmosomes are able to sequester plakoglobin and so regulate its signalling activity in the same way that adherens junctions are apparently able to modulate β-catenin signalling (Gottardi et al, 2001; Kuphal and Behrens, 2006), but this is by no means is certain.
In part that may be because of the perception that they are so regulated and controlled in every other way that there is nothing they can do about problems and they have got to go to the police to solve them.
"Entry is so regulated and there are watchers everywhere who'd observe the first sign of anything out of the ordinary... the possibility of that kind of an attack feels like a freak occurrence".
"Everything is so regulated, so limited, everything's super uptight," she said.
