In agreement with these data, we also observed a significant downregulation of genes belonging to this GO class : the mean ratio between 40 day heads and 3 day heads was 0.84 and several genes implicated in rhodopsin mediated phototransduction (ninaC, inaC, inaD, Arr1) were repressed more than 1.5 times.
Ninety-five genes were identified that distinguished the samples from all four autoimmune diseases from healthy controls, including those encoding the cell surface receptors TGFBR2, CSF3R, and BMPR2, which were overexpressed in the autoimmune patients, and several genes implicated in apoptosis (TRADD, TRAF2, CASP6, CASP8), which were underexpressed.
BACKGROUND: Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL.
In addition to CORM-3 effects on iron homeostasis, targeting of the cell membrane is indicated here as a major casualty of CORM-3 stress, by both CORM-enhanced NPN fluorescence assays of membrane integrity (Fig. 8) and upregulation of several genes implicated in stress responses at the membrane and in the periplasm.
Hypercorticosteronemia has been described in LXR deficient mice [32], and these mice overexpress several genes implicated in steroid metabolism (StAR, CYP11A1 and 3β-HSD-1).
105, 106 Additional to mutations in PIK3CA and P53, alterations in several genes implicated in pathways involved in breast tumorigenesis, including the phosphatidylinositol 3-kinase/Akt and NF-kB pathways, have been also identified (eg, IKBKB, IRS4, NFKBIA, NFKBIE, NFKB1, PIK3R1, PIK3R4, RPS6KA3, MAP3K1, AKT1, and GATA3 genes).
As indicated by the GO terms, the gene list includes epigenetic regulators, such as Hdac11, Hdac6, Hdac5, Fbxl11, Mbd3, Tlk1, Mll3, Cbx4 and Cbx6 as well as several genes implicated in brain development and plasticity: Arc, Egr1/2, Suds3, Aof2, Mta2, Syp and Magee1.
In the present study, we examined calcium deposition in OA menisci and investigated the expression of several genes implicated in the biomineralization biological process, including ENPP1, ANKH and matrix Gla protein.
Intracellularly, YopM seems at least partly to be localized in the nucleus [16], [17], [18] and one study using microarray analysis found the dysregulation of several genes implicated in cellular growth and cell cycle control [19].
Columbia and NewYork-Presbyterian research has shown that several genes implicated in rare forms of pediatric epilepsy also contribute to common forms of the disorder.
