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The estimates of specificity and sensitivity will be reported as percentages with 95% CIs.
For example, in screening women aged 40 49 years, both MST and sensitivity will be lower.
Great care and sensitivity will be exercised in identifying these groups as membership of a lower status caste and poverty are stigmatising.
TopHat will miss spliced alignments to reads with mismatches in the seed region of the splice junction, but we expect this tradeoff between speed and sensitivity will be favorable for most users.
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However, value of HbA1c only reflects glucose levels over a longer time frame and its sensitivity will be limited to individuals with IGT and diabetes.
Lewke: "International and intercultural sensitivity will be crucial for CIOs.
The next step will be mRNA sequencing, a technique still in its infancy and whose sensitivity will be challenged by the high prevalence of alternatively spliced variant occurring at low copy number and that may be to the consequence of splicing noise [29].
Experimentally testing the effect of changes in BRAF/CRAF on RAF inhibitor-induced phenotypes and RAFi sensitivity will be very interesting.
Beta cell function and insulin sensitivity will be assessed using validated modelling methods based on an OGTT or a mixed-meal tolerance test (MMTT), as well as empirical indices [ 14, 15].
The slopes of progression of HbA1c, indexes of β-cell function and insulin sensitivity will be analysed using a similar random coefficient model as used for the rate of loss of glycaemic control over time.
This can be seen intuitively since the size of the prevalence pool will be the incidence (I) times the average time spent in the prevalence pool (M), and the sensitivity will be the proportion of these tumours detectable at first screen.
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