The addition of a non-native PTM can alter a protein in two ways; firstly, it can lead to biochemical dysfunction, and secondly, it can cause crosstalk in which a native (and potentially functionally necessary) PTM cannot be added or removed because of steric hindrance caused by an inhibitory modification at a structurally proximal amino acid.
Secondly, can regional and spatial patterns concerning spatial homogamy be identified?
First, the predictor variables are all explicitly defined and can be readily assessed at the time of patient presentation, and secondly, patients can be assigned to their appropriate risk class on the basis of information from the initial history alone.
From the review of related work, we conclude: Firstly, the smartphone can be used to capture the behavior of it's user and secondly, teams can be characterized by network metrics as commonly applied in social network analysis.
Firstly, they can be used in an attempt to tell whether two trees are actually the same and, secondly, they can be used to indicate the degree of similarity between two trees with respect to some criterion.
And secondly, how can it be improved?
And secondly, researchers can post their CVs online.
And secondly, how can "order" come from "disorder"... That's an easy one since you don't have to rely on complex biological arguments.
"The general rule is don't combine SSRIs with MDMA," he says, adding that, firstly, we don't know everything we need to know about this drug interaction; and secondly, reactions can be highly idiosyncratic and difficult to predict.
