Sentence examples similar to and resulting hyperactivation of from inspiring English sources

Interestingly, when PTEN was selectively deleted in granule cells (with resulting hyperactivation of mTOR), spontaneous epilepsy, granule cell hypertrophy and mossy fibre sprouting occurred [ 36].

Here, we report that deletion of Wfs1 from layer 2/3 pyramidal cells impairs the ability of the mPFC to suppress stress-induced depressive behaviors, and results in hyperactivation of the hypothalamic pituitary adrenal axis and altered accumulation of important growth and neurotrophic factors.

A systems biology approach to search for putative EGFR-TKI resistance mechanisms by comparing biopsies from NSCLC patients before and after the development of EGFR-TKI resistance revealed that EGFR gene amplification and PIK3CA mutations resulting in hyperactivation of the PI3K signaling pathway also may drive EGFR-TKI resistance in vivo.

Plasmalogen deficiency mediated by GNPAT or Pex7 knockout in mice impairs membrane recruitment and activation of Akt, resulting in hyperactivation of glycogen synthase kinase 3β (GSK3β), which inhibits Schwann cell differentiation (Fig. 4).

We selected the RHEB mutations to obtain experimental evidence for our hypothesis that de novo changes in mTOR-related genes are likely due to a gain-of-function mechanism, resulting in hyperactivation of mTOR, as previously shown for other syndromic neurodevelopmental cases associated with macrocephaly.

It has been shown that p53 and SAPK (stress-activated protein kinase) pathways cooperatively regulate PLK4 activity, and inactivation of both p53 and MKK4 genes result in hyperactivation of PLK4 which often causes supernumerary centrosomes as frequently found in cancer cells [ 26].

Learned helplessness, a behavioral model for anxiety and affective disorders, is dependent on 5-HT activity in the DRN and is proposed to result from hyperactivation of 5-HT neurons in the DRN during exposure to uncontrollable stress (67), leading to internalization of inhibitory serotonin 1A autoreceptors, thus sensitizing other DRN 5-HT neurons to subsequent stress (68,69).

Moreover, there may be certain situations where certain potent BRAF mutations (Val→Glu) and RAS mutations are not permitted in the same cell, as they might result in hyperactivation of Ras/Raf/MEK/ERK signaling and expression, which could lead to cell cycle arrest [ 75].

In particular, >90% of CRC exhibit mutations in the Adenomatous polyposis coli (APC) gene and in other Wnt signaling components that result in hyperactivation of the Wnt pathway, and these mutations are the earliest known genetic alterations, indicating that they represent the initiating event in the path to CRC [ 2, 5, 6].

Inhibition of the MDM2 p53 interaction using either Nutlin-3 or MDM2 RNA interference resulted in hyperactivation of the p53 pathway and a strong induction of apoptosis in cisplatin-sensitive and -resistant TC cells.

Hence, alteration (e.g., activation and inactivating mutations) of genes (e.g., PTEN, KRAS, and LKB1) whose products regulate the mTOR axis will result in hyperactivation of the axis in certain types of cancers.