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Decreased ChAT expression and resultant decrease in ACh release from motor nerve ends can lead to dysfunction of motor synapses at axon terminals (30, 31).
Thus, inactivation of this pathway in intestinal epithelial cells results in a direct reduction of tumour incidence, whereas its inactivation in myeloid cells, which cause inflammation, results in a reduction of pro-inflammatory cytokines and resultant decrease in tumour size [ 15].
The data also suggest that the mechanism maintaining insulin sensitivity in the absence of TNF-α may involve redirection of the fat deposition to the metabolically more inert subcutaneous depot or decreases in circulating resistin and resultant decrease in liver fat deposition.
Chloride infusions increase delivery to the macula densa that stimulates glomerulotubular feedback leading to afferent arteriole constriction, mesangial contraction and resultant decrease in GFR [ 31].
It can be hypothesized that the diminished expression of SR-BI and resultant decrease in uptake of HDLC may contribute to the increase in HDLC levels seen after administration of bile acid sequestrants in humans [ 15, 22].
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Within aged care, privatisation was linked to plummeting levels of staff, especially qualified staff, and resultant decreases in the levels of care.
The present study used fat-1 transgenic mice, that are capable of synthesizing n-3 fatty acids, to investigate the influence of increases in n-3 fatty acids and resultant decreases in the n-6∶n-3 rationon liver mitochondrial H2O2 production and electron transport chain (ETC) activity.
Simultaneously, we determined the impact of these forced deficits in NAD(P H and resultant decreases in GSH on neurodegeneration (Fig. 3D F).
Mutations in the α-Gal A gene (GLA) occur in the rare, X-linked lysosomal storage disorder called Fabry disease, and resultant decreases in α-Gal A enzymatic activity lead to the progressive and widespread accumulation of glycosphingolipids in most bodily tissues and fluids including Gb3 and globotriaosylsphingosine (also known as lyso-Gb3) [ 1, 2].
In GD, the point mutations within the GBA (glucosidase, beta, acid) gene lead to the production of acid β-glucosidase with functional, kinetic, trafficking, and/or stability defects and a resultant decrease in lysosomal function and increase in the accumulation of glucosylceramide and glucosylsphingosine.
The phenotypes of both VirA and EspG were attributed specifically to Rab1 inactivation and the resultant decrease in ER-Golgi transport (Dong et al., 2012), and a model of EspG activity has been proposed where EspG interacts with ARF1 at the cis-Golgi membrane and deactivates the local Rab1 population resulting in bidirectional ER-Golgi trafficking arrest (Selyunin et al., 2014).
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