Sentence examples for and resultant activation of from inspiring English sources

Pharmacological inhibition or siRNA ablation of AR attenuates TNF-α and growth factor-induced IκBα phosphorylation and degradation and resultant activation of NF-κB thereby preventing the cytotoxic effects in vascular smooth muscle cells (VSMC), vascular endothelial cells (VEC) and human lens epithelial cells (HLEC) [12] [15].

IKZF1 mutants are associated with increased STAT5 expression and resultant activation of the JAK STAT pathway (Jager et al. 2010).

However, information addressing any possible proinflammatory and resultant activation of pro-atherothrombotic responses in type 1 diabetes during hypoglycemia is scarce.

Low amounts of p27Kip1 in the nucleus and resultant activation of cyclin-dependent kinases in the nucleus may increase the proliferation of tumor cells [ 30, 31].

Due to high prevalence of PTEN mutations and resultant activation of PI3K/AKT pathway, stabilization of HIF-1 α and activation of various target genes are frequently observed in endometrial cancer cells.

Group-I receptors are coupled to activation of PLC and a resultant activation of PKC (protein kinase C) and release of intracellular calcium stores.

We ascribed the enhancement of the rate performance to the suppression of the Jahn-Teller distortion of Mn3+ and the resultant activation of the Mn reduction reaction.

Although relatively little is known about the function of POGZ, a recent study detailed the interaction of the zinc finger domain of POGZ with HP1α and the resultant activation of Aurora B kinase [ 22].

Activation of plasma membrane receptors and the resultant activation of rapid signaling pathways can also alter gene expression, either by ligand-independent ER activation of gene expression secondary to phosphorylation of the ER or altering levels of co-activators and co-repressors or by activating ER-independent signals that alter gene expression.

These changes would significantly disrupt the interplay between the apoptotic regulatory proteins causing the resultant activation of Bak and Bax and the induction of apoptosis.

It would be interesting to see the role of matriptase, if any, on the proteolytic processing of this protein, resultant activation of the kinase and its effect on such tumors.