Until recently, investigations had focused on defining diuretic and natriuretic responsiveness based on change in body weight or urine output relative to the dose of furosemide administered [8, 9, 11, 12].
Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the unique potential to predict therapeutic responsiveness for individual patients.
This particular information may allow to construct a new screening procedure for Parkinson's disease diagnose and to determine drug trial responsiveness based on a non-invasive, fMRI-based investigation in the future.
Next, during dobutamine infusion to maximally stimulate the adrenergic response in the heart, LCR and HCR rats showed similar inotropic responsiveness based on significant increases in the ejection fraction (EF) and maximal positive pressure derivative (+dP/dt) (Figure 3 and Table 3).
To compare responsiveness based on item response theory (IRT) with that based on conventional scoring for two patient-reported outcomes measures in carpal tunnel syndrome (CTS); the short disabilities of the arm, shoulder, and hand (QuickDASH) measure, and the 6-item CTS symptoms scale (CTS-6).
Prediction of fluid responsiveness based on SVVFloTrac, SVVPiCCO, PPV and static preload variables (CVP and GEDV) was tested by calculating the AUC (area under the receiver operating characteristic [ROC] curve) for a SV increase greater than 25%.
We developed the criterion that genomic occurrence of paired HREs at an inter-HRE distance less than 200 bp predicts hormone responsiveness, based on synergy of multiple HREs, and HRE information from known target genes.
The definitions of these responsiveness domains were adapted from the WHO model of evaluating responsiveness based on users of the health insurance system [ 9, 10] and are presented in Table 1.
This paper is an early attempt to further elaborate RRI's concept of responsiveness based on recent practical examinations in private sector R&D.
To our knowledge, this was the first study to evaluate the value of IJVV in predicting fluid responsiveness based on a standard fluid challenge in mechanically ventilated cardiac surgical patients.
