Upon loss of the pS127, YAP1 is permissive for activation but requires additional modifications for nuclear localization and transcriptional transactivation [ 15, 16, 29, 39], which we find are dependent on loss of the RASSF1A transcript and expression of RASSF1C.
This method requires additional modifications prior to standard library preparation.
Extending the model to non-European populations, particularly from Asia and Africa, may therefore require additional modifications and perhaps re-estimation of the model parameters.
The presence of HPV infection alone also is not sufficient to cause tumorigenesis and requires additional cellular modifications such as alterations in the p53 and K-ras genes.
Thus, PEGPLA hydrogels are excellent candidates for short-term (< 14 days) acute release of therapeutic factors in the retina, but will <span class="lh lhl">require additional modifications for application with neural prostheses.
Differences between yeast Rfa2 and human RPA2 might simply be caused by cellular complexity (e.g., human RPA interacts with proteins not found in yeast cells and might require additional modification to regulate these interactions).
This gene therapy is effective in mice, but for application in the clinic, the vector will require additional modification to improve safety and the components for tetracycline gene regulation will need to be engineered to prevent immunogenicity.
It is known that NF-κB factors (already liberated from the IκB complex) require additional modification through phosphorylation, for example [ 46, 47].
The method involves a low-expertise and scalable dip coating process and does not require additional surface modification or external stimulus.
A previous report indicated that in vitro translated AhR/ARNT does not bind to the XRE-II motif, suggesting that in vivo binding requires additional proteins or posttranslational modification(s) [12].
Despite much progress, neither paradigm provides a silver bullet for conservation's most pressing problems, and both require additional thought and modification to become maximally effective.
