The phrase "and require a substantial" is correct and usable in written English.
It can be used when discussing the need for a significant amount of something, often in a formal or academic context.
Example: "The project demands extensive resources and require a substantial investment of time and effort to complete successfully."
Alternatives: "and necessitate a considerable" or "and call for a significant".
However, high-level theoretical calculations are very intensive computationally and require a substantial time investment, limiting their application to small/medium size molecules.
On the other hand, it would certainly impact the time needed to import new molecules, and require a substantial amount of additional disk space.
Many coastal and ocean processes of interest operate over large temporal and geographical scales and require a substantial amount of computational resources, particularly when engineering design and failure scenarios are also considered.
German Health Services Research Data Bank VfD_DMSV_13_002152 Oral diseases rank among the most prevalent non-communicable diseases in modern societies and require a substantial due of health care systems.
Designing and evaluating complex interventions to improve health care pose a considerable challenge and require a substantial investment of time and financial resource [ 48] but nevertheless remain a key priority for clinical research into musculoskeletal disease.
With current GWAS typically including hundreds of thousands of SNPs, this implies both a computational and statistical burden even for groups sizes as small as k = 2: the numerous tests takes days and even weeks to compute and require a substantial correction for multiple hypothesis, leading in some cases to a loss of power (Evans et al., 2006).
When the Tarantinos bought the property in 1988, it was in poor condition and required a substantial renovation.
However, it was computationally cumbersome and required a substantial amount of speech from each speaker in order to estimate the best warp factor.
While it is possible to screen large databases in their entirety using automated high-throughput screening methods, this is expensive and requires a substantial investment in infrastructure and assay development.
Multiple modifications have been attempted to facilitate construction of the anastomoses, which has been recognized as a technical challenge and requires a substantial learning curve to achieve acceptable reproducibility [ 27].
Despite that the recent development of next generation sequencing (NGS) techniques has facilitated the de novo development of SSRs, this task is still quite expensive and requires a substantial amount of time [ 5].
