The phrase "and represent a significant" is correct and usable in written English.
It can be used when discussing the importance or impact of something in a particular context.
Example: "The findings of this study are crucial and represent a significant advancement in our understanding of climate change."
Alternatives: "and signify an important" or "and indicate a considerable".
Transportation barriers are common among patients with chronic diseases and represent a significant impediment to improving patient outcomes.
Antipsychotic-associated side effects are well known and represent a significant treatment challenge.
"The results of these UK-backed vaccine trials are hugely promising and represent a significant breakthrough in our battle against this deadly disease.
Thrombocytopenia occurs in pediatric patients after SCT and has to be treated with platelet transfusions which bear certain risks and represent a significant cost factor.
The inspections and tests undertaken following completion of the cabling installation are generally termed as final acceptance testing and represent a significant contractual interface.
The novel analytical solutions are accurate, easily implementable and thoroughly verified, and represent a significant improvement to current approaches found in design standards.
These symptoms are currently challenging to treat with deep brain stimulation, and represent a significant source of debility and quality of life concerns for those living with advanced Parkinson's disease.
These data have provided a wealth of new information on the fluid flows generated by the body, tail, and fins of freely swimming fishes, and represent a significant new arena of investigation.
Dense fibrous connective tissues play critical load-bearing roles in the musculoskeletal system and represent a significant medical problem when their function is interrupted by progressive degeneration or acute injury.
Focusing on global health, the most important breakthroughs we have identified are: Collectively, HIV/Aids, Malaria and TB kill almost four million people a year, and represent a significant disease burden for low-income populations in sub-Saharan Africa and South Asia.
Economists and financial analysts at the Federal Reserve and elsewhere pay close attention to auto sales because they are one of the first economic indicators to come out each month, and because they tend to be highly cyclical and represent a significant portion of the nation's economic output.
