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Such changes have been correlated with different states of DNA transcription and replication in the cell.
These findings are consistent with a model in which intracellular T. cruzi amastigotes capitalize on the host metabolic response to parasite infection, including the increase in glucose uptake, to fuel their own metabolism and replication in the host cytosol.
Compared with a conventional TRAD, TRAD-DNIκBα showed hepatocyte-specific inhibition of NF-κB signaling and significantly reduced Ad gene expression and replication in the normal human hepatocyte cell line.
An infection, by contrast, is the invasion of and replication in the body by any of various microbial agents—including bacteria, viruses, fungi, protozoans, and worms as well as the reaction of tissues to their presence or to the toxins that they produce.
Indeed, many novel genes involved in virus entry and replication in the host have been uncovered (Brass et al., 2008; Brass et al., 2009).
Therefore, the LPS O-antigen and/or the O-antigen capsule are essential to F. tularensis persistence in macrophages and replication in the host.
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Following digestion, ligation, transformation and replication in E.coli, the plasmids were extracted and screened for the target plasmid via 0.8% agarose gel electrophoresis.
The involvement of PCBP2 in the switch between translation and replication in polioviruses highlights the importance of host-cell RNA binding proteins in this process [57].
In both cases, we have observed that m6A addition significantly increases viral gene expression and replication in culture and, in the case of IAV, we also observed that m6A addition increases viral pathogenicity in mice.
Inactivation of bacteriophages was observed in vitro after incubation with chitosan, inhibiting both the infection of, and replication in bacterial cells, and the transduction of eukaryotic cells.
The unbalanced distribution of the demographic characteristics in the discovery and replication samples in the present study might partly contribute to the lack of replication.
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