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The phrase "and regardless of" is correct and usable in written English.
It is often used as a way to introduce a new thought that is not necessarily related to the thought that came before it. For example: "I will always strive to do what is best for my family, and regardless of the challenges that come my way."
Exact(60)
And regardless of vehicle driven, too.
"And regardless of what happens, it's fine for me.
And regardless of the name, that's the point.
And regardless of orthodoxy, I felt punk wasmessianic.
And regardless of the injuries, I'm still a great player.
Southerland: Regardless of science and regardless of the law.
"And regardless of the situation, we've been sticking with it".
And, regardless of their show's fate, they decided they would remain through the school year.
And regardless of his policies, he comes into office facing a deficit of public trust.
And regardless of how experienced, careful and dedicated we are, accidents do and will happen".
And regardless of its intentions, the Brotherhood has hardly represented a force of change.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com