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After several well-defined water molecules were added and a further five cycles of refinement performed, TPQ was rebuilt with occupancy of 0.5 for each conformation and refined with a final B-factor of around 25 Å for each.
Hydrogen atoms were inserted in calculated positions and refined with a riding model.
The sequential process map is shown in Figure 1 and the HTA diagram is shown in Figure 2. The procedure for this phase of the study was pilot tested and refined with a group of postgraduate students working in healthcare and studying a module in patient safety.
Besides my grandfather, Uncle Stan was always my favorite among the male relatives of that generation: witty, charming, and refined, with a deceptively sweet and gentle way of being sardonic and even, on occasion, sharp-tongued.
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Initial marker order was determined with the command "formLinkageGroup" and refined with the command "ripple" with a seven markers window.
The infrastructure of Chinese repression is being enhanced and refined, with the implementation of a new "grid" system of street-level surveillance (see article).
A coding framework will be developed based on the emerging analysis, and then tested and refined with subsequent interviews in an iterative process.
Partly based on these inputs, the team then developed prototypes that were 'validated and refined' with focus groups recruited by an agency.
Structures were determined with molecular replacement and refined with Phenix.
The structure was modified using Coot 31) and refined with Refmac5.
Five heavy atom sites were identified and refined with SHELEXD.
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