Others have previously described a role for CRTC in enabling hunger-dependent LTM in the fly [ 24] and promoting persistent memory in the mouse [ 25].
Oral vancomycin and metronidazole promote persistent high concentrations of VRE in stool, further increasing the risk for shedding of VRE into the environment and onto skin [ 4].
A prolonged period of medication abuse may increase the incidence of CSD events, or consequence of CSDs, to initiate signalling in the trigeminovascular system to enhance the frequency of migraine headaches, and, consequently, to promote persistent cephalic and extracephalic cutaneous allodynia [32].
Conversely, insufficient Th1 cells responses (which are required for resolving C. trachomatis infection and clearing HPV) may promote persistent C. trachomatis and persistent HPV infection [ 31- 33].
We targeted these two end-binding proteins because EB1 and EB3, but not EB2 promote persistent microtubule growth, and also knockdown of EB1-3 is not possible (Komarova et al., 2009).
In pyramidal cells (but not in interneurons) this effect depended on NMDA receptor activation and was hypothesized to promote persistent firing [32].
These conditions might promote persistent and non-physiological T-cell activation in autoimmunity [ 70].
Recently, we have shown that M. tb recruits mesenchymal stem cells (MSCs) to granulomas to promote persistent infection and Treg expansion in infected mice [14].
Chronic tissue damage and inflammation have been associated with tumor development as well as EMT [ 13, 31, 32], conditions that may promote persistent microtubule stability and aberrant detyrosinated tubulin elevation.
An age-dependent increase in body burden of Cd and chronic exposure of the prostate to Cd may promote persistent inflammation, which is associated with increased cell proliferation and evasion of apoptosis, favoring neoplastic transformation in the prostate.
