Higher proportion of longer delays in certain groups of patients depicts the barriers in health care access and prolongation in delays in diagnosis among those population [ 23, 28].
We study results for a region close to the Patagonian Andes and their prolongation in the Antarctic Peninsula, which is well-known for the generation by topography of intense stratospheric GW, specially during winter and spring.
We first conducted descriptive analyses to compare arsenic exposure data and demographic and lifestyle characteristics between the present study population and the overall cohort, and between participants with and without QTc prolongation in the study population.
There was a significant reduction in the value of df and a corresponding prolongation in the GT in the heparin group as compared with the healthy group.
The sodium channel block provokes a widening of QRS interval and QT interval prolongation in the ECG, caused by a prolongation of total activation time due to decreased conduction velocity, in agreement with previous studies (Salata and Wasserstrom, 1988; Bezzina et al., 2006).
In children older than 5 years (there were not enough controls under 5 years old to make comparisons), Kissinger and others 17 and Van Vugt and others 26 showed a prolongation in the objective ABR (longer I III IPLs) compared with the controls without artemisinin treatment.
The PBPK-QTc modeling would likely suggest an appreciable QTc prolongation with terfenadine alone and a dramatic QTc prolongation in the presence of ketoconazole mirroring described clinical experience.
The combination of CPT-11 with 5FU LV has not only led to a 15% increase in the response rate and a 3-month prolongation in the median progression-free time with respect to traditional 5FU LV regimens, but has also resulted in a 2 3-month increase of median survival (Douillard et al, 2 3-monthtz et al, 2000).
However, one cannot refute the possibility that the catecholamine surge may influence the QT interval indirectly via hypokalemia, because hypokalemia (as well as hypocalcemia and hypomagnesemia) can cause a prolongation in the QT interval [ 4, 7- 9].
Blockade of the delayed rectifier potassium channel current, IKr, has been associated with drug-induced QT prolongation in the electrocardiogram and life-threatening cardiac arrhythmias.
