Sentence examples for and profound decrease in from inspiring English sources

In two randomized controlled studies and 2 recent meta-analyses, rasburicase administration was associated with a more rapid and profound decrease in uricaemia as compared with allopurinol [209 211].

The rapid and profound decrease in smoking is probably the single most important factor.

We found a significant and profound decrease in vascularity and neoangiogenesis in both skin and synovium after treatment.

There is now no doubt that this reversal of diabetes depends upon the sudden and profound decrease in food intake, and does not relate to any direct surgical effect.

The effect of MDR P. aeruginosa clinical isolates on TER of Caco-2 cells following apical inoculation is summarized in Figure 2. Dynamic tracking of TER following apical exposure of Caco-2 cells to P. aeruginosa (Fig. 2A) (Fig. 2B) demonstrated that the strains 1, 13, and that of RAPD type G20 induced a rapid and profound decrease in TER similar to the highly cytotoxic strain PA103 [ 21].

In summary, letrozole produces rapid and profound decreases in expression of Ki67 and PgR but changes do not always correlate with clinical and pathological responses.

Consistent with this finding, Miller and colleagues also reported that neoadjuvant letrozole produces rapid and profound decreases in expression of Ki67 and PgR that do not always correlate with clinical and pathological responses [ 47].

Although the underlying mechanism remains uncertain, it is known that robatumumab induces IGF-1R degradation 20 and profound decreases in blood counts of IGF-1R-positive PBMCs were observed in normal subjects in the first-in-human study of robatumumab (unpublished).

Higher parasite loads were reported in helminth-infected animals [20], increased severity of malaria infections (a non lethal P. yoelii strain becomes lethal), alteration of innate responses, and a profound decrease in Th1 responses [22].

SAHA was able to increase histone H3 and H4 protein and acetylation levels, and caused a profound decrease in the protein levels of key molecules, PCNA and E2F-1, essential for DNA synthesis.

A recent study demonstrates that wild-type magA+ and trans-complemented magA organisms grow more rapidly and cause a more profound decrease in ERG a- and b-waves and cellular infiltration in a mouse model than the magA deficient organism [29].