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From an immunologic viewpoint, this makes the previous concepts of antigen discovery for cancer vaccines impractical and problematic, with the implication that one of the soundest approaches would employ autologous tumor cells.
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"I am afraid that we are on the verge of something much greater and much more problematic with the U.S. economy".
Our findings suggest that good quality building design in ECH can support the quality of life of residents, but that designing features that support the needs of both relatively independent and frail users is problematic, with the needs of highly dependent users not currently supported as well as could be hoped by ECH schemes.
Buying spare parts on the black market has also become more problematic with the new sanctions on financial transactions.
That is what is problematic with the Christian ideology".
Recruitment was not problematic, with the majority of eligible families consenting to participate in the intervention.
In the toxicity analysis for TAS-106, the most common and problematic toxicities associated with the study medication were myelosuppression and infections.
With minimal and problematic coverage in the history textbooks, there is little curriculum for teachers hoping to provide students with the crucial history of the Black Panther Party.
With resistance to current treatments becoming increasingly problematic and with the lack of any vaccine, novel anthelmintics are urgently required [ 3].
Zelda's burst of dedicated professionalism -- in the year or so that was left to her before she had a series of nervous breakdowns and became a lifelong mental patient, she practiced from 8to1010 hours a day -- would eventually be held against her as yet another indication of her eccentricity and problematic competitiveness with her acclaimed spouse, the writer F. Scott Fitzgerald.
The building of both bridges was problematic, with both the first and second bridges requiring several redesigns from multiple architects.
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