However, when full-length membrane reconstituted syntaxin is examined, pulse EPR demonstrates that the configuration of the protein is different and predominantly in an open state.
AKT1 E17K activating mutations were observed in 3 out of 4 datasets and predominantly in Luminal A tumors (14 out of 20).
Most of the shifts (67%) were found in the Agaricales and predominantly in the Paleogene, consistent with a dynamic evolutionary history of the order but also with its largest share of diversity in the class.
Nowadays, signals are generated and processed predominantly in a digital form, and the presentation of stimuli is controlled by a computer, as opposed to analog equipment such as tone/noise generators, filters or mixers.
With these antibodies we were able to show that mBcl-G is localised in the cytoplasm and predominantly expressed in a wide range of epithelial cells and in spermatids.
In order to protect against oncogenic mutations, most immature adult stem cells are thought to divide infrequently and be predominantly in a quiescent state (reviewed in [1]).
Double immunofluorescence revealed an intimate spatial relationship between CD34+ HSPCs and CD271+ MSCs; remarkably, 86% of CD34+ HSPCs were in direct contact with CD271+ MSCs across benign, MDS and AML marrows, predominantly in a perivascular distribution.
Likewise, alanine mutation of two residues flanking the other side of the aromatic cage (H48 and E49) results predominantly in a loss of specificity (Additional file 1: Figure S5a).
Somatic mutations in GATA3 occurred in 58 cases (10.7%), predominantly in luminal A and B cancer subtypes, an additional 12 samples displayed copy number alterations (http://www.cbioportal.org).org
Our structural data demonstrate that the nucleotide-dependent FRET changes correspond to an ∼17 nm swing of the motor N terminus and that this occurs predominantly in a plane parallel to the right-view plane.
