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However, these agents cannot be used alone because their short half-life can lead to recrudescence, and potentially the development of drug resistance [15], [16].
Severe oxidative stress can lead to cellular damage, resulting in further hepatic inflammation, and potentially the development of heptatic steatosis and insulin resistance [ 34- 38].
The early start of chemotherapy might be interesting since surgery provokes the circulation of neoplastic cells (Yamaguchi et al, 2000) and angiogenesis and potentially the development of micrometastasis.
In the latter two cases, novel biological pathways involved in the disease state may be uncovered, leading to a better understanding of disease processes and potentially the development of novel therapies.
Oncologists agree that an early start for chemotherapy is rationally correct, because surgery provokes the circulation of neoplastic cells (Yamaguchi et al, 2000), angiogenesis, and, potentially, the development of micrometastasis, as Dr Alliot indicated.
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Moreover, genes belonging to the TGF-beta signalling pathway, which are supposedly targeted by the miRNAs differentially expressed in our work, regulate the chondrocyte differentiation and potentially the OA development [ 57].
It is also setting up an Office of Unconventional Gas and Oil, to monitor and potentially aid the development of the new industry.
These findings suggest that MBG-independent, between-patient differences in HbA1c are predictive of AGE burden in the skin and potentially influence the development of diabetes complications.
We propose that dacarbazine-based therapy response rates and likelihood of resistance may be shifted to favor patient outcome by the introduction of ABT-263, the orally available form of ABT-737, to enhance the pro-apoptotic effect of chemotherapy to eliminate cancer cells from the body and potentially reduce the development of chemoresistance.
Finding GDF8 (myostatin) to be upregulated in healthy first degree relatives in this study suggests that this factor could play an initiating role in the muscle wasting observed in many diabetic patients and potentially in the development of insulin resistance in the prediabetic stage.
The new model proposed here can act as a stand-alone equation for the LKE, making it portable and potentially facilitating the development of new transition models tailored to various industrial applications.
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CEO of Professional Science Editing for Scientists @ prosciediting.com