The phrase "and pose a substantial" is correct and usable in written English.
It can be used when discussing potential risks, challenges, or impacts that are significant in nature.
Example: "The new policy changes may lead to unforeseen consequences and pose a substantial threat to our current operations."
Alternatives: "and present a significant" or "and create a major".
Chronic and end stage renal disease (ESRD) have reached pandemic levels and pose a substantial public health burden.
Such infections are a significant source of illness and pose a substantial economic burden on health services and society, in general [1].
Both sexes of goshawk are dominant over buzzards [26], often take over buzzard territories and pose a substantial predation threat to both buzzard nestlings and adults.
Pesticides commonly occur in aquatic systems and pose a substantial challenge to the conservation of many taxa.
Further, OP and other anticholinesterase agents are extensively used as pesticides and pose a substantial occupational and environmental risk.
While the overall survival of patients with cSCC is high, these tumours are associated with considerable morbidity and pose a substantial financial burden for health-care systems.
Chronic migraine afflicts 1-51-5% the global population and poses a substantial burden on subjects' quality of life and on health services utilization[1].
Andrade has looked extremely dangerous in recent fights and poses a substantial challenge for the champion who dethroned longtime queen Joanna Jedrzejczyk.
Avian malaria primarily affects species of the order Passeriformes, and poses a substantial threat to birds of Hawaii, the Galapagos, and other archipelagoes.
In addition, testing, processing, and storage of blood products is generally far from a high standard and poses a substantial risk of transfusion reactions and transmission of infectious diseases [10].
