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The phrase "and pose a significant" is correct and usable in written English.
It can be used when discussing challenges, risks, or impacts that are considerable or noteworthy in a particular context.
Example: "The new regulations may create additional hurdles and pose a significant challenge to small businesses trying to comply."
Alternatives: "and present a major" or "and create a substantial".
Exact(27)
Trans-fats have no health benefits and pose a significant risk for heart disease, but the case for saturated fat is less clear," Dr de Souza said.
But if a flight is delayed, this form of electronic solitary confinement can last a lot longer — and pose a significant hardship for those desperate to connect.
On occasion, scleritis can be severe enough to destroy areas of the sclera and pose a significant threat to the health and visual function of the eye.
He added: "I will now weigh carefully the options available to me as the matters which are at stake are constitutionally very significant and pose a significant threat to the rights of constituents and public representatives in performing their duty.
They persist in the environment and pose a significant health threat especially to humans.
Benches and berms have normally used to stop rocks before to fall prior and pose a significant hazard.
Similar(31)
"The programme employs a wide variety of malicious software, and poses a significant threat to UK networks.
In employment, the chances are they will still face discrimination, while a lot of transphobic crime goes unreported and poses a significant problem for police.
That report follows the National Academy of Sciences and the vast majority of scientists by stating that global warming is real and poses a significant threat.
Mr. Hockenberry (Reading from a National Academy of Sciences report): "Climate change is occurring and is largely caused by human activities and poses a significant risk for a broad range of human and natural systems".
Hydrofluoric acid, though cheap and readily available, is rather hazardous to handle and poses a significant health risk.
More suggestions(13)
and pose a considerable
and pose a huge
and bring a significant
and raises a significant
and cause a significant
and mark a significant
and raise a significant
and represents a significant
and causes a significant
and occupy a significant
and represent a significant
and constitute a significant
and present a significant
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com