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For example, the zinc finger protein Wt1, acts upstream of Brn3b, and plays a role in the development of RGCs.
Serine/threonine kinase (STK15; Mis:603072) is a regulator of mitotic chromosomal segregation (Dutertre et al, 2002) and plays a role in the development of malignancy (Bischoff et al, 1998; Zhou et al, 1998; Ewart-Toland et al, 2003).
UCHL1, also called protein gene product 9.5 (PGP9.5), is a member of the ubiquitin carboxyl-terminal hydrolase family and plays a role in the development of many tumor types via aberrant promoter methylation [ 22, 23].
The gene encodes a member of the eyes absent protein family of transcription factors and plays a role in the development of the eye and inner ear in humans [ 7, 70].
With regard to cancer and metastasis formation, substance P causes an increase of the basal-like human breast carcinoma cell line MDA-MB-468 [ 24], and plays a role in the development of bone marrow metastases in breast cancer and neuroblastoma [ 55].
Rhomboid (Rho; ↓45d glia, MN+glia) is a serine protease that regulates epidermal growth factor signaling by cleaving the growth factor Spitz (Urban et al. 2001) and plays a role in the development of the nervous system (Bier et al. 1990; Salzberg et al. 1994; Sepp and Auld 2003).
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It plays a role in the development of economic bubbles.
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The latter plays a role in the development of addiction.
It may also have played a role in the development of culture.
ERFE may play a role in the development of AI.
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