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These results suggested that CgIFNR-3 could bind to CgIFNLP as an interferon receptor and participate in the activation of JAK/STAT pathway in human, which will benefit for intensive studies of interferon signaling pathway in mollusc.
In addition, the inflammasome, that is composed of leucine-rich-repeat-containing proteins and nucleotide-binding domain (NLRPs) can act as sensors of PAMPs and DAMPs and participate in the activation of lipid peroxidation and ROS production during NAFLD/NASH progression (Thuy et al., 2008, Harte et al., 2010, Henao-Mejia et al., 2012).
Intracellular ROS are known as potent inducers of p53 and participate in the activation of p53 by chemotherapeutic drugs [45].
Based on these observations it is possible that ctsk is able to localize in subcellular compartments other than the lysosome and participate in the activation of metabolic pathways.
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Kexins participate in the activation of peptide hormones, growth factors, and viral proteins [ 74].
In addition, Ets-1 was reported to participate in the activation of BNP gene [31].
Type I transmembrane MT-MMPs participate in the activation of the zymogen form of MMP2 (pro-MMP2).
In synergy with various cis-acting elements, these motifs participate in the activation of expression.
The Rheb/mTOR pathway was reported to participate in the activation of IRF7.
Therefore, our data confirmed that both intrinsic and extrinsic pathways of apoptosis participating in the activation of caspase-3, and then in the related apoptosis activation.
It participates in the activation of SNAP receptors (SNAREs), which are membrane associated proteins necessary for membrane fusion [2].
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