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Finally, decision limits for sensitive, specific and optimal recognition of vitamin B12 status with individual parameters were derived.
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However, this seems unlikely as studies by Brinkworth et al. showed that, when using prediction models for substrates of kinases, the basic amino acids lysine (K) and arginine (R) are often required for optimal recognition of substrates [34].
42 This compromises optimal recognition of coronary heart disease in women and might thereby explain part of the observed sex differences in first manifestation of cardiovascular disease in our study.
In addition, variable side chain contribution may also reflect optimal recognition of specific nucleotide sequences.
Altogether, these data suggest that optimal recognition of the recombinant proteins by MMR requires the presence of both N-mannosylation and extensive O-mannosylation while DC-SIGN relies primarily on O-mannosylation.
Optimal recognition of the TAA is affected by the extracellular length of the CAR.
We have shown that the proline residue within the PINK1 TM domain appears to be required for optimal recognition of PINK1 by PARL as a substrate.
Both CA25 and UP30 signal sequences resulted in less presentation of INV on the cell surface than Y21, consistent with optimal recognition of the yeast Y21 sequence over either of the two human signal sequences.
This interaction is allosterically regulated by binding of B-cell CLL/Lymphoma 9 protein (Bcl9) to a site distinct from the H3-binding pocket, resulting in stabilization of conformational rearrangements that shape Pygo1 for optimal recognition of H3K4me2 (56).
Even in physician-manned services, lack of training and sub-optimal recognition of the indications for advanced airway management may influence outcomes [ 47- 49].
Among caspase family members, caspase 2 is unique because it has features of both the long prodomain of upstream caspases and the optimal recognition motif of downstream caspases (Harvey et al, 1997; Droin et al, 2001).
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