The study was based on interviews with a rotating sample of 7,500 households in 2000 and 2001, and on diaries kept by an additional 7,500 people for two consecutive one-week periods.
A handheld electronic diary (HED) that can be used throughout the day may provide more useful and accurate information about pain, treatments, and function than available paper and on-line diaries that are designed to be used once daily, weekly or less often.
These 'solicited symptoms' (local symptoms: pain, swelling; generalized symptoms: drowsiness, fever, irritability, loss of appetite) were graded and recorded on diary cards.
We solicited adverse events (AEs) by asking subjects to record injection site symptoms (injection site pain, redness, and swelling) and general symptoms (fever, fatigue, headache, pain behind the eyes, abdominal pain, nausea, vomiting, muscle ache, joint ache, diffuse rash on the trunk, photophobia, and pruritis) on diary cards for 21 days after each vaccination.
Virginia had kept a diary, off and on, since 1897.
Twenty-nine (63 %) participants had recorded pulse oximetry, symptoms and other COPD-related information on diary sheets and had kept this information.
At the end of the 12-week intervention phase, objective lung function tests and patient-rated day and nighttime symptoms based on diary recordings showed little or no change.
For the project, Mr. Garrett was an assistant editor on "Diary and Autobiography of John Adams" (1961), a four-volume work edited by L. H. Butterfield.
Lower intensities are accepted if the patient cannot comfortably reach the maximal device intensity and will be noted on diary logs.
Treatment compliance was verified based on diary records and by review of empty blisters and unused study medication.
