While there are several specific OGA inhibitors, the complexity, high cost, and limited versatility of classical OGT assays, in addition to the enzyme's instability during purification, have been major obstacles in developing potent and selective OGT inhibitors.
We also face many implementation obstacles in developing POS, like the incompatibility between Pig data model and Storm data model, the bolts partition problem in topology generation procedure.
TODS abstracts away from service logic most complexities of data management, which have often become major obstacles in developing high quality Internet services.
Prime obstacles in developing an efficient subdivision-based polynomial constraint solver are the exhaustive, although hierarchical, search of the zero-set in the parameter domain, which is computationally demanding, and their scalability in terms of the number of variables.
The optimal design results in this paper are expected to provide a design guideline for multi-axis F/T sensors with significantly reduced cross coupling error, one of the biggest technical obstacles in developing F/T sensors.
Therefore, today one of the major obstacles in developing next generation vaccines is the need for effective adjuvants available for clinical trials.
One of the main obstacles in developing Kv7 channel active drugs has been to identify compounds that can discriminate between the neuronal subtypes, a feature that could help diminish side effects and increase the potential of drugs for particular indications.
A lack of high quality health information is one of the major obstacles in developing appropriate preventative strategies for NCDs at the national level [ 18].
