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At generations 5 and 6, fecundity of the high-fat diet dropped, indicating strong purifying selection and necessitating a reduction in the fat content from coconut oil from 3 to 1.5%, at which point viability and fecundity returned.
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PACs can differentiate between pulmonary hypertension and RV ischaemia, necessitating a reduction of RV afterload, as the ischaemic RV is very sensitive to any afterload increase [ 54].
The high-fat diet resulted in high morbidity and loss of fecundity, necessitating a reduction in coconut oil concentration at generation five, but no gross loss of viability was observed for the high-sugar and low-sugar diets.
The DLT was diarrhoea, necessitating a reduction in the dose of 5-FU.
3– 7 Indeed, some patients complain of hypoglycemia before dawn, necessitating a reduction in the NPH insulin dose at bedtime.
Neutropenia is one of the most important dose-limiting toxicities of cytotoxic drugs, often necessitating a reduction from the initial dosage (Crawford et al, 2004).
Withdrawal and rebound symptoms commonly occur and necessitate a gradual reduction in dosage to minimize withdrawal effects when discontinuing.
The transition to a low carbon energy portfolio necessitates a reduction in the demand of fossil-fuel and an increase in renewable energy generation and penetration.
Addition of the soil-plant component, which necessitated a reduction in the RFR, caused no changes in effluent quality, and its role in the treatment remained undetermined.
Many current employees of The Times-Picayune and NOLA.com will have the opportunity to grow with the new organizations, but the need to reallocate resources to accelerate the digital growth of NOLA Media Group will necessitate a reduction in the size of the workforce.
All of these classroom strategies necessitate a reduction in course content.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com