Sentence examples for and mutations of a from inspiring English sources

Once that system locks on to its target, it can make adjustments, too, shaping the response to match the contortions and mutations of a tumor in real time.

Virus-induced apoptosis and neuronal injury produce an N-terminal SMN cleavage product (∼29 kDa) and mutation of a predicted caspase cleavage site, D252A, blocks this cleavage [46].

Moreover, lysyl oxidases are copper-dependent enzymes, and mutation of a copper transporting ATPase in a background of copper-deficiency results in post-embryonic vertebral defects similar to those described here for col27a1a and col27a1b morphants [35].

A mutation switched the allelic status; mutation of a 0 allele produced a 1 allele and mutation of a 1 allele produced a 0 allele.

Members of this subgroup are characterized by an extended C-terminal half of the α-subunit arising by expansion and mutation of a sequence repeat.

Rather, mutation of an AP1 site at -737 in the LAMB3 promoter reduced basal promoter activity and mutation of a second AP1 site at -3.5 kb abrogated TGFβ responsiveness.

The equal potency of Apc loss and mutation of a single β-catenin allele at transforming Lgr5-positive cells was somewhat surprising given the high frequency of APC mutations in human CRC.

The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.

Deletions and mutations of these two motifs resulted in a significant reduction in binding affinity.

Propagating the mutant collection for a sufficiently long duration allowed us to identify both beneficial and deleterious mutations of a wide range of strengths.

This example demonstrates the power of haplogrouping as a tool for quality control by highlighting missing and private mutations of a sample in question.