Deletion and mutation of the DR5, but not the IR6 element, abolished the atRA-mediated activity.
Interestingly, SMRT is recruited to PPARγ via its C-terminal interacting domain, and mutation of the proximal interacting domain does not interfere with recruitment via PPARγ.
We analyzed the thermal regime and the water accumulation and mutation of the water heat exchange based on the continuous in-situ water heat monitoring data in air and soil from 2013 to 2014.
Resistance to cytarabine was explained by a new homozygous deletion of the DCK gene, whereas methotrexate resistance was associated with monoallelic deletion of FPGS and mutation of the remaining allele.
As one of the pioneers of the body horror genre, a subgenre of horror flicks where the main focus is on the degradation and mutation of the human body, he's managed to skillfully oscillate throughout his career between more mainstream pictures such as The Fly and History of Violence and rather underground productions like Videodrome.
Not only is the nurse is the first person in the world confirmed to have contracted the virus outside West Africa, the apparent manner of her infection, with no known physical contact with an Ebola sufferer, will concern medical experts studying the spread and mutation of the disease.
Both neomycin treatment and mutation of the phospholipid-binding site reduced the association of tTG with recycling endosomes and inhibited its secretion.
It is possible that the "unprotected" plasmid DNA corresponding to the ZNF 3' exons serves as a recombination template, resulting in recombination and mutation of the introduced gene.
The proximal 5'UTR was inhibitory to translation in reporter gene experiments, and mutation of the secondary structure motif increased translational efficiency.
Phosphorylation kinetics are similar to those of other active kinases, and mutation of the ATP-binding lysine (K220 within subdomain 2) causes marked reduction in enzymatic activity.
Our finding is consistent with previous findings that the C-terminus of HDAC1 mediates its interactions with cofactors [49] and mutation of the HDAC1 sumoylation sites does not disrupt cofactor binding [37].
